Technology Process of 2-(2-(2-(ethoxymethoxy)propan-2-yl)-5-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 7 articles about 2-(2-(2-(ethoxymethoxy)propan-2-yl)-5-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
1,4-dioxane; water;
at 80 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium nitrite; sulfuric acid / 2 h / 20 °C
2.1: thionyl chloride / Reflux
3.1: hydrogen; palladium 10% on activated carbon / 760.05 Torr
4.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 °C
4.2: 1 h / 0 - 20 °C
5.1: methyl magnesium iodide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation
7.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; methyl magnesium iodide; thionyl chloride; potassium nitrite; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium nitrite; hydrogen bromide / water / 0.5 h / 0 °C
1.2: 1 h / 0 - 20 °C
2.1: methyl magnesium iodide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation
4.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 80 °C / Inert atmosphere
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; methyl magnesium iodide; hydrogen bromide; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
