methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Base Information

Chemical Name:methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate
CAS No.:904679-61-4
Molecular Formula:C₁₈H₁₇F₂NO₄S
Molecular Weight:381.4
Hs Code.:

Synonyms:methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Suppliers and Price of methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

There total 5 articles about methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947-65-9
methyl 2-hydroxy-1-naphthoate

: 904679-61-4
methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / H₂ / Pd/C / methanol; H₂O / 2.5 h / 60 °C / 77572.2 Torr

2: pyridine / CH₂Cl₂ / -20 - 20 °C

3: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

4: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

5: pyridine / 20 °C

With pyridine; hydrogenchloride; palladium diacetate; hydrogen; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; 3: Buchwald reaction;
DOI:10.1021/jm0601001

Reference yield:

: 846540-87-2
2-trifluoromethanesulfonyloxy-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

: 904679-61-4
methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 54.06 g / Cs₂CO₃; Pd(OAc)2; 4,5-bis-diphenylphosphanyl-9,9-dimethyl-9H-xanthene / dioxane / 4 h / 100 °C

2: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

3: pyridine / 20 °C

With hydrogenchloride; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; pyridine; 1: Buchwald reaction;
DOI:10.1021/jm0601001

Reference yield:

: 900492-90-2
2-(benzhydrylidene-amino)-5,6,7,8-tetrahydronaphthalene-1-carboxylic acid methyl ester

: 904679-61-4
methyl 2-{[(2,6-difluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / aq. HCl / tetrahydrofuran / 1 h / 20 °C

2: pyridine / 20 °C

With hydrogenchloride; In tetrahydrofuran; pyridine;
DOI:10.1021/jm0601001