methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Base Information

Chemical Name:methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate
CAS No.:1380753-47-8
Molecular Formula:C₁₆H₁₄ClF₂N₃O₂
Molecular Weight:353.756
Hs Code.:

Synonyms:methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Suppliers and Price of methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

There total 2 articles about methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380752-61-3
tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate

: 67754-03-4
methyl 2,5-dichloronicotinate

: 1380753-47-8
methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Guidance literature:: tert-butyl 3-((2,4-difluorophenyl)amino)azetidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; for 1h;

methyl 2,5-dichloronicotinate; With triethylamine; In tetrahydrofuran; methanol; at 75 ℃; for 12h;

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1380753-47-8
methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 168 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

2.2: 12 h / 75 °C

With sodium tris(acetoxy)borohydride; acetic acid; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1380753-47-8
methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate

: 1380754-03-9
5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinic acid

Guidance literature:: methyl 5-chloro-2-(3-((2,4-difluorophenyl)amino)azetidin-1-yl)nicotinate; With sodium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 12h;

With hydrogenchloride; In 1,4-dioxane; water; pH=1;