phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate

Base Information

• Chemical Name: phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate
• CAS No.: 132776-12-6
• Molecular Formula: C₂₂H₁₇FOS
• Molecular Weight: 348.441
• Mol file: 132776-12-6.mol

Synonyms:phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate

Chemical Property of phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate

There total 3 articles about phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate (132775-99-6) → phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate (132776-12-6) + (+)-(R)-1-fluoro-2,2-diphenylcyclopropane (132776-06-8)

Guidance literature:

With thiophenol; In benzene; for 0.5h; Heating;

DOI:10.1021/jo00006a042

Reference yield:

N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate (132775-99-6) + thiophenol (108-98-5) → phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate (132776-12-6) + (+)-(R)-1-fluoro-2,2-diphenylcyclopropane (132776-06-8) + diphenyldisulfane (882-33-7)

Guidance literature:

In benzene; for 0.5h; Heating;

DOI:10.1021/jo00006a042

Reference yield:

(+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarbonyl chloride (132776-08-0) → phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate (132776-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / CH₂Cl₂ / Ambient temperature

2: thiophenol / benzene / 0.5 h / Heating

With thiophenol; In dichloromethane; benzene;

DOI:10.1021/jo00006a042

upstream raw materials:

N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate

thiophenol

(+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarbonyl chloride