N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate

Base Information

• Chemical Name: N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate
• CAS No.: 132775-99-6
• Molecular Formula: C₂₁H₁₆FNO₂S
• Molecular Weight: 365.428
• Mol file: 132775-99-6.mol

Synonyms:N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate

Chemical Property of N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

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Technology Process of N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate

There total 1 articles about N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-mercaptopyridine-1-oxide sodium salt (3811-73-2) + (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarbonyl chloride (132776-08-0) → N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate (132775-99-6)

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1021/jo00006a042

Reference yield: 45.0%

N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate (132775-99-6) → 2,5-difluoro-1,1,6,6-tetraphenyl-1,5-hexadiene (57719-68-3) + (+)-(S)-1-chloro-1-fluoro-2,2-diphenylcyclopropane (132776-02-4) + (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylic acid (30724-79-9,33666-38-5) + (+)-(S)-1-fluoro-1-(2'-pyridylthio)-2,2-diphenylcyclopropane (132776-01-3)

Guidance literature:

In tetrachloromethane; at 40 ℃; for 1h; Further byproducts given. Yields of byproduct given; Irradiation;

DOI:10.1021/jo00006a042

Reference yield: 38.0%

N-(2-thioxypyridinyl) (+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarboxylate (132775-99-6) → phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropanethiocarboxylate (132776-12-6) + (+)-(R)-1-fluoro-2,2-diphenylcyclopropane (132776-06-8)

Guidance literature:

With thiophenol; In benzene; for 0.5h; Heating;

DOI:10.1021/jo00006a042

upstream raw materials:

2-mercaptopyridine-1-oxide sodium salt

(+)-(R)-1-fluoro-2,2-diphenylcyclopropanecarbonyl chloride

Downstream raw materials:

2,2'-dipyridyldisulphide

phenyl (+)-(R)-1-fluoro-2,2-diphenylcyclopropaneselenocarboxylate

(+)-(R)-1-fluoro-2,2-diphenylcyclopropane

1-fluoro-1-(phenylseleno)-2,2-diphenylcyclopropane