Technology Process of 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1'-biphenyl]-3-yl)acetic acid
There total 6 articles about 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1'-biphenyl]-3-yl)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; lithium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 14h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 20 °C
3: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C
4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxyethane / 16 h / 110 °C / Inert atmosphere; Sealed tube
5: lithium hydroxide; water / tetrahydrofuran; methanol / 14 h / 20 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); camphor-10-sulfonic acid; water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C
3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 20 °C
4: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C
5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) / 1,2-dimethoxyethane / 16 h / 110 °C / Inert atmosphere; Sealed tube
6: lithium hydroxide; water / tetrahydrofuran; methanol / 14 h / 20 °C
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); camphor-10-sulfonic acid; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
![ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate](/Databaselist/images/loading.webp)
