ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

Base Information

Chemical Name:ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate
CAS No.:1454928-12-1
Molecular Formula:C₃₃H₃₉N₃O₄
Molecular Weight:541.69
Hs Code.:

Synonyms:ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

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Chemical Property of ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

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Technology Process of ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

There total 5 articles about ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1198615-70-1
ethyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate

: 1454928-11-0
3-(((4-bromobenzyl)oxy)methyl)-1-(4-(tert-butyl)benzyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

: 1454928-12-1
ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,2-dimethoxyethane; at 110 ℃; for 16h; Inert atmosphere; Sealed tube;

Reference yield:

: 873-75-6
4-bromobenzenemethanol

: 1454928-12-1
ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 20 °C

4: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C

5: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 110 °C / Inert atmosphere; Sealed tube

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; camphor-10-sulfonic acid; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1,2-dimethoxyethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 82499-60-3
<(p-bromobenzyl)oxy>acetic acid

: 1454928-12-1
ethyl 2-(4'-(((1-(4-(tert-butyl)benzyl)-4-ethyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methoxy)methyl)-[1,1 '-biphenyl]-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 14 h / 20 °C

2: camphor-10-sulfonic acid / ethyl acetate / 16 h / 80 °C

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 110 °C / Inert atmosphere; Sealed tube

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; camphor-10-sulfonic acid; N-ethyl-N,N-diisopropylamine; HATU; In 1,2-dimethoxyethane; ethyl acetate; N,N-dimethyl-formamide;