N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester

Base Information

• Chemical Name: N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester
• CAS No.: 468071-23-0
• Molecular Formula: C₃₆H₄₄N₄O₈
• Molecular Weight: 660.767

Synonyms:N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester

Chemical Property of N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester

Chemical Property:

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Technology Process of N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester

There total 1 articles about N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine (152120-55-3) + Nβ-benzyloxycarbonyl-Nε-methyl-(S)-β-lysine tert-butyl ester hydrochloride → Nβ,Nω,Nω'-tris(benzyloxycarbonyl)-Nε-methyl-(S)-β-homoarginine tert-butyl ester (468071-23-0)

Guidance literature:

With triethylamine; In dichloromethane; Heating;

DOI:10.1021/jm0111191

Reference yield: 88.0%

Nβ,Nω,Nω'-tris(benzyloxycarbonyl)-Nε-methyl-(S)-β-homoarginine tert-butyl ester (468071-23-0) + methyl iodide (74-88-4) → Nβ,Nω,Nω'-tris(benzyloxycarbonyl)-Nε,Nω-dimethyl-(S)-β-homoarginine tert-butyl ester (468071-29-6)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In acetone; at 60 ℃; for 48h;

DOI:10.1021/jm0111191

Reference yield: 59.0%

Nβ,Nω,Nω'-tris(benzyloxycarbonyl)-Nε-methyl-(S)-β-homoarginine tert-butyl ester (468071-23-0) → Nβ,Nω,Nω'-tris(benzyloxycarbonyl)-Nε-methyl-(S)-β-homoarginine (468071-25-2)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at -5 ℃;

DOI:10.1021/jm0111191

upstream raw materials:

N,N-bis(benzyloxycarbonyl)-1H-pyrazole-1-carboxamidine

Downstream raw materials:

N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε-methyl-(S)-β-homoarginine

N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε,N^ω-dimethyl-(S)-β-homoarginine tert-butyl ester

N^β,N^ω,N^ω'-tris(benzyloxycarbonyl)-N^ε,N^ω-dimethyl-(S)-β-homoarginine

(3'S,5RS)-5-[N-[3-benzyloxycarbonylamino-6-[2,3-di(benzyloxycarbonyl)-1-methylguanidin-1-yl]hexanoyl]-N-methylamino]-5,6-dihydro-2-ureidopyrimid-4(1H)-one

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