Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

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Chemical Name:Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide
CAS No.:1437316-70-5
Molecular Formula:C₂₀H₁₈F₂N₆O₂S
Molecular Weight:444.465
Hs Code.:

Synonyms:Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

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Chemical Property of Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

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Technology Process of Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

There total 10 articles about Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1093101-49-5
4-(2-fluoropyrimidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine

: 1103234-57-6
N-(3-amino-2,4-difluorophenyl)propane-1-sulfonamide

: 1437316-70-5
Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

Guidance literature:: With hydrogenchloride; In water; tert-butyl alcohol; at 150 ℃; for 2h; Microwave irradiation;

Reference yield:

: 13671-00-6
methyl 2,6-difluorobenzoate

: 1437316-70-5
Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 2 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

3.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

5.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

5.2: 80 °C

6.1: hydrogenchloride / water; tert-butyl alcohol / 2 h / 150 °C / Microwave irradiation

With pyridine; hydrogenchloride; sulfuric acid; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 84832-02-0
methyl 3-amino-2,6-difluorobenzoate

: 1437316-70-5
Ν-((3-(3-(7-hydro-pyrrolo[2,3-d]-6-yl)pyrimidin-4-yl)pyridin-2-ylamino)-2,4-difluorobenzene-yl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 1,2-dichloro-ethane / 5 h / 100 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / 20 - 80 °C

3.2: 80 °C

4.1: hydrogenchloride / water; tert-butyl alcohol / 2 h / 150 °C / Microwave irradiation

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; water; 1,2-dichloro-ethane; tert-butyl alcohol;