2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

Base Information

Chemical Name:2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione
CAS No.:1351409-39-6
Molecular Formula:C₂₀H₂₈FN₅O₃
Molecular Weight:405.472
Hs Code.:

Synonyms:2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

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Chemical Property of 2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

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Technology Process of 2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

There total 4 articles about 2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 762-49-2
2-fluoroethyl bromide

: 903528-73-4
2-{4-[4-(2-hydroxyphenyl)piperazin-1-yl]butyl}-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

: 1351409-39-6
2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:

Reference yield: 54.0%

: 903528-73-4
2-{4-[4-(2-hydroxyphenyl)piperazin-1-yl]butyl}-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

: 383-50-6
2-fluoroethyl tosylate

: 1351409-39-6
2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: With caesium carbonate; In acetonitrile; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 913734-73-3
1-(2-(2-fluoroethoxy)phenyl)piperazine

: 179756-87-7
2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

: 1351409-39-6
2-(4-{4-[2-(2-fluoroethoxy)phenyl]piperazin-1-yl}butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione

Guidance literature:: 2-(4-chlorobutyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione; With sodium iodide; In acetonitrile; for 0.5h; Reflux;

1-(2-(2-fluoroethoxy)phenyl)piperazine; With potassium carbonate; In acetonitrile; at 60 ℃; for 24h;
DOI:10.1016/j.bmcl.2014.07.048