{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester
CAS No.:1378040-48-2
Molecular Formula:C₂₂H₂₁Cl₂N₇O₂
Molecular Weight:486.36
Hs Code.:

Synonyms:{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

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Chemical Property of {6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

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Technology Process of {6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

There total 6 articles about {6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364663-35-3
6-amino-(pyrimidin-4-yl)-bis-carbamic acid tert-butyl ester

: 1378040-46-0
4-bromo-2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridine

: 1378040-48-2
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

: 1378040-47-1
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 354112-08-6
tert-butyl N-tert-butoxycarbonyl-N-(6-chloropyrimidin-4-yl)carbamate

: 1378040-48-2
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

: 1378040-47-1
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 4 h / 70 °C

2: palladium on activated charcoal / ethyl acetate; industrial methylated spirits / 18 h / 20 °C / Inert atmosphere

3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With sodium azide; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; industrial methylated spirits; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1365992-75-1
(6-azidopyrimidin-4-yl)-bis-carbamic acid tert-butyl ester

: 1378040-48-2
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-carbamic acid tert-butyl ester

: 1378040-47-1
{6-[2-(2,6-dichlorophenyl)-7-methyl-2H-pyrazolo[4,3-c]pyridin-4-ylamino]-pyrimidin-4-yl}-bis-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on activated charcoal / ethyl acetate; industrial methylated spirits / 18 h / 20 °C / Inert atmosphere

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; industrial methylated spirits; ethyl acetate;