(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

Base Information

Chemical Name:(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide
CAS No.:1370016-94-6
Molecular Formula:C₂₃H₂₈F₃N₇O₃
Molecular Weight:507.516
Hs Code.:

(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

Synonyms:(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

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Chemical Property of (E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

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Technology Process of (E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

There total 5 articles about (E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288963-81-4
(Z)-2-fluoro-N'-hydroxy-2-methylpropanimidamide

: 1369872-11-6
1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylic acid

: 1370016-94-6
(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

Guidance literature:: 1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)piperidine-4-carboxylic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; for 0.5h;

(Z)-2-fluoro-N'-hydroxy-2-methylpropanimidamide; In acetonitrile; for 16h;

Reference yield:

: 455-87-8
4-amino-3-fluorobenzoic acid

: 1370016-94-6
(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h / 0 - 20 °C

2.1: caesium carbonate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2 h / 102 °C / Inert atmosphere

3.1: triethylamine; lithium bromide / acetonitrile; water / 16 h / 50 - 75 °C

3.2: pH 1 / Cooling with ice

4.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h

4.2: 16 h

With caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; lithium bromide; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; water; acetonitrile;

Reference yield:

: 536748-06-8
4-amino-3-fluoro-N,N-dimethylbenzamide

: 1370016-94-6
(E)-1-(6-(4-(dimethylcarbamoyl)-2-fluorophenylamino)-5-fluoropyrimidin-4-yl)-N-(2-fluoro-1-(hydroxyimino)-2-methylpropyl)piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / palladium diacetate; 1,1'-bis(di-tertbutylphosphino)ferrocene / 1,4-dioxane / 2 h / 102 °C / Inert atmosphere

2.1: triethylamine; lithium bromide / acetonitrile; water / 16 h / 50 - 75 °C

2.2: pH 1 / Cooling with ice

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 0.5 h

3.2: 16 h

With caesium carbonate; triethylamine; 1,1'-carbonyldiimidazole; lithium bromide; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; water; acetonitrile;