[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

Base Information

Chemical Name:[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate
CAS No.:1050504-41-0
Molecular Formula:C₃₇H₄₆N₈O₁₂
Molecular Weight:794.819
Hs Code.:

[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

Synonyms:[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

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Chemical Property of [(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

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Technology Process of [(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

There total 10 articles about [(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1050504-38-5
(3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine

: 1050504-40-9
(3R,4S)-4-[(benzoyloxy)methyl]-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-aminium 2,2,2-trifluoroacetate

: 1050504-41-0
[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 1050504-40-9
(3R,4S)-4-[(benzoyloxy)methyl]-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-aminium 2,2,2-trifluoroacetate

: 1613255-81-4
t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]carbamate

: 1050504-41-0
[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1007/s00706-014-1251-4

Reference yield:

: 1050504-29-4
[(3S,4R)-4-amino-1-[(S)-1-phenylethyl]pyrrolidin-3-yl]methanol

: 1050504-41-0
[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / methanol / 2 h / 20 °C

2: dmap / dichloromethane / 1 h / 20 °C

3: dichloromethane / 0.5 h / 0 °C

4: methanol / 0.67 h / Reflux

5: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; dichloromethane / 12 h / 20 °C

6: dichloromethane / 1 h / 20 °C

7: triethylamine / dichloromethane / 12 h / 20 °C

With methanol; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-014-1251-4