(3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine

Base Information

• Chemical Name: (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine
• CAS No.: 1050504-38-5
• Molecular Formula: C₂₄H₂₉N₅O₁₀
• Molecular Weight: 547.522

Synonyms:(3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine

Chemical Property of (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine

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Technology Process of (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine

There total 1 articles about (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]carbamate (1050504-37-4) + 4-Nitrophenyl chloroformate (7693-46-1) → (3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine (1050504-38-5)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 ℃; for 1.5h;

Reference yield: 60.0%

(3S,4R)-4-((4-nitrophenoxy)carbonyloxymethyl)-3-t-butoxycarbonylamino-1-thymidyacetylpyrrolidine (1050504-38-5) + (3R,4S)-4-[(benzoyloxy)methyl]-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-aminium 2,2,2-trifluoroacetate (1050504-40-9) → [(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate (1050504-41-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

upstream raw materials:

t-butyl [(3R,4S)-4-(hydroxymethyl)-1-[2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetyl]pyrrolidin-3-yl]carbamate

4-Nitrophenyl chloroformate

Downstream raw materials:

[(3S,4R)-4-[({[(3S,4R)-4-{[(tert-butoxy)carbonyl]amino}-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methoxy}carbonyl)amino]-1-[2-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)acetyl]pyrrolidin-3-yl]methyl benzoate

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