ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

Base Information

Chemical Name:ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate
CAS No.:1379461-22-9
Molecular Formula:C₁₇H₂₄O₆
Molecular Weight:324.374
Hs Code.:

Synonyms:ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

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Chemical Property of ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

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Technology Process of ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

There total 3 articles about ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1134445-70-7
ethyl (2E)-3-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]acrylate

: 1774-47-6
trimethylsulfoxonium iodide

: 1379461-22-9
ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 0 - 20 ℃; for 1h;

ethyl (2E)-3-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]acrylate; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 48.3333h;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 1379461-22-9
ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1.17 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / 20 °C

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 0 - 20 °C

3.2: 48.33 h / 20 °C

With sodium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide; acetonitrile; mineral oil; 1.1: Wittig reaction / 3.1: Corey-Chaykovsky cyclopropanation / 3.2: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 1379461-22-9
ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

2.1: dichloromethane / 1.17 h / 0 - 20 °C

3.1: potassium carbonate / acetonitrile / 2 h / 20 °C

4.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 0 - 20 °C

4.2: 48.33 h / 20 °C

With sodium hydride; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile; mineral oil; 1.1: Mitsunobu reaction / 2.1: Wittig reaction / 4.1: Corey-Chaykovsky cyclopropanation / 4.2: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmc.2012.03.036