2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

Base Information

Chemical Name:2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid
CAS No.:1379461-35-4
Molecular Formula:C₁₉H₁₇ClF₃NO₅
Molecular Weight:431.796
Hs Code.:

Synonyms:2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

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Chemical Property of 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

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Technology Process of 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

There total 5 articles about 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1379461-23-0
ethyl 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylate

: 1379461-35-4
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

Guidance literature:: ethyl 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylate; With sodium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 0.5h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 1379461-35-4
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 1.17 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / 20 °C

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 0 - 20 °C

3.2: 48.33 h / 20 °C

4.1: hydrogenchloride; water / acetone / 6 h / 50 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 20 °C

6.2: 20 °C

With hydrogenchloride; water; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil; 1.1: Wittig reaction / 3.1: Corey-Chaykovsky cyclopropanation / 3.2: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 1379461-22-9
ethyl 2-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]cyclopropanecarboxylate

: 1379461-35-4
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / acetone / 6 h / 50 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 20 °C

3.2: 20 °C

With hydrogenchloride; water; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2012.03.036