2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

Base Information

Chemical Name:2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide
CAS No.:1379461-24-1
Molecular Formula:C₂₄H₂₈ClF₃N₂O₆S
Molecular Weight:565.01
Hs Code.:

Synonyms:2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

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Chemical Property of 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

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Technology Process of 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

There total 7 articles about 2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 52960-14-2
1-pentylsulfonamide

: 1379461-35-4
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]cyclopropanecarboxylic acid

: 1379461-24-1
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 1379461-24-1
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 1.17 h / 0 - 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / 20 °C

3.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 0 - 20 °C

3.2: 48.33 h / 20 °C

4.1: hydrogenchloride; water / acetone / 6 h / 50 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 20 °C

6.2: 20 °C

7.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With hydrogenchloride; dmap; water; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil; 1.1: Wittig reaction / 3.1: Corey-Chaykovsky cyclopropanation / 3.2: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 1134445-70-7
ethyl (2E)-3-[4-(2-methoxyethoxy)-2-(methoxymethoxy)phenyl]acrylate

: 1379461-24-1
2-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-N-(pentylsulfonyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 1 h / 0 - 20 °C

1.2: 48.33 h / 20 °C

2.1: hydrogenchloride; water / acetone / 6 h / 50 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 20 °C

4.2: 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With hydrogenchloride; dmap; water; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile; mineral oil; 1.1: Corey-Chaykovsky cyclopropanation / 1.2: Corey-Chaykovsky cyclopropanation;
DOI:10.1016/j.bmc.2012.03.036