N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

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Chemical Name:N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide
CAS No.:1361324-77-7
Molecular Formula:C₃₇H₃₈F₃N₃O₃
Molecular Weight:629.722
Hs Code.:

Synonyms:N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

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Chemical Property of N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

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Technology Process of N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

There total 4 articles about N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 62506-76-7
2-(4-methylphenyl)pyrrolidine

: 1361325-40-7
N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

: 1361324-77-7
N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

Guidance literature:: N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 22 ℃; for 0.5h;

2-(4-methylphenyl)pyrrolidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 22 ℃; for 16h;

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 1361324-77-7
N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

1.2: 5 h / 22 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 22 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

3.2: 16 h / 22 °C

With lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: (2R,3S)-3-amino-4-phenyl-1-(3-trifluoromethyl-benzylamino)-butan-2-ol dihydrochloride

: 1361324-77-7
N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-3-(2-p-tolyl-pyrrolidine-1-carbonyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

1.2: 5 h / 22 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 22 °C

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

3.2: 16 h / 22 °C

With lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide;