N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

Base Information

Chemical Name:N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid
CAS No.:1361325-40-7
Molecular Formula:C₂₆H₂₅F₃N₂O₄
Molecular Weight:486.491
Hs Code.:

Synonyms:N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

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Chemical Property of N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

Chemical Property:

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Technology Process of N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

There total 4 articles about N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361325-39-4
N-[(1S,2R)-1-Benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-iso phthalamic acid methyl ester

: 1361325-40-7
N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 22 ℃; for 16h;

Reference yield:

: 1877-71-0
benzene 1,3-dicarboxylic acid monomethyl ester

: 1361325-40-7
N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

1.2: 5 h / 22 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 22 °C

With lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: (2R,3S)-3-amino-4-phenyl-1-(3-trifluoromethyl-benzylamino)-butan-2-ol dihydrochloride

: 1361325-40-7
N-[(1S,2R)-1-benzyl-2-hydroxy-3-(3-trifluoromethyl-benzylamino)-propyl]-isophthalamic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.5 h / 22 °C

1.2: 5 h / 22 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 16 h / 22 °C

With lithium hydroxide monohydrate; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In tetrahydrofuran; N,N-dimethyl-formamide;