(S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide

Base Information

• Chemical Name: (S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide
• CAS No.: 1446671-08-4
• Molecular Formula: C₂₀H₃₁NO₄S
• Molecular Weight: 381.536
• Mol file: 1446671-08-4.mol

Synonyms:(S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide

Chemical Property of (S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide

There total 1 articles about (S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-oct-1-en-3-ol (3391-86-4,3687-48-7,50999-79-6,24587-53-9) + N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide (18303-04-3) → (S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide (1446671-08-4)

Guidance literature:

With 1,2-bis-(diphenylphosphino)ethane; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201300375

Reference yield: 97.0%

(S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide (1446671-08-4) → (S)-4-methyl-N-(oct-1-en-3-yl)benzenesulfonamide (1446671-12-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201300375

Reference yield:

(S)-N-(1-vinylhexyl)-N-(tert-butoxycarbonyl)-p-toluenesulfonamide (1446671-08-4) → (S)-(1-{[tosyl(1-vinylhexyl)amino]methyl}vinyl)phosphonic acid diethyl ester (1446671-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / toluene / 1 h / 20 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1002/ejoc.201300375

upstream raw materials:

(S)-oct-1-en-3-ol

N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

Downstream raw materials:

(S)-4-methyl-N-(oct-1-en-3-yl)benzenesulfonamide

(S)-(1-{[tosyl(1-vinylhexyl)amino]methyl}vinyl)phosphonic acid diethyl ester

(S)-[5-pentyl-1-tosyl-2,5-dihydro-1H-pyrrol-3-yl]phosphonic acid diethyl ester