N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

Base Information

Chemical Name:N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide
CAS No.:1311166-15-0
Molecular Formula:C₁₇H₁₂ClFN₂O₃S
Molecular Weight:378.811
Hs Code.:

Synonyms:N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

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Technology Process of N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

There total 3 articles about N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1269791-34-5
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)acetamide

: 121-33-5,8014-42-4
vanillin

: 1311166-15-0
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1002/ardp.201100072

Reference yield:

: 101337-93-3
2-amino-6-fluoro-7-chloro-1,3-benzothiazole

: 1311166-15-0
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1 h / Reflux

2: sodium hydroxide / ethanol / 20 °C

With sodium hydroxide; In ethanol; 2: Claisen Schmidt condensation;
DOI:10.1002/ardp.201100072

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 1311166-15-0
N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-hydroxy-3-methoxyphenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 14 h / 5 - 20 °C

2: 1 h / Reflux

3: sodium hydroxide / ethanol / 20 °C

With bromine; acetic acid; sodium hydroxide; In ethanol; 3: Claisen Schmidt condensation;
DOI:10.1002/ardp.201100072