N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Name:N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:201420-72-6
Molecular Formula:C₅₂H₄₇N₅O₆Si
Molecular Weight:866.061
Hs Code.:

Synonyms:N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

There total 10 articles about N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 201420-70-4
N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 201420-72-6
N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 110 ℃; for 4h;
DOI:10.1021/jo971703a

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 201420-72-6
N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 48 h / Ambient temperature

2: 93 percent / Et₃N, DMAP / toluene / 15 h / Ambient temperature

3: 91 percent / Bu₃SnH, AIBN / toluene / 4 h / 110 °C

With dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethylamine; In pyridine; toluene;
DOI:10.1021/jo971703a

Reference yield:

: 98-88-4
benzoyl chloride

: 201420-72-6
N-(9-{(2R,3aS,7aR)-7a-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5,5-diphenyl-hexahydro-1,4-dioxa-5-sila-inden-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) pyridine, room temp., 5 h, 2.) pyridine, room temp., overnight

2: CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) (COCl)2, DMSO, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1.5 h, 2.) CH₂Cl₂, -78 deg C, 30 min, 0 deg C, 1.5 h

4: 72 percent / Bu₄NBH₃CN / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 0 deg C, 1.5 h

5: 1.) K₂CO₃, 2.) NH₃ / 1.) MeOH, room temp., 10 min, 2.) MeOH, 10 min

6: 100 percent / pyridine / 48 h / Ambient temperature

7: 93 percent / Et₃N, DMAP / toluene / 15 h / Ambient temperature

8: 91 percent / Bu₃SnH, AIBN / toluene / 4 h / 110 °C

With dmap; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonia; tri-n-butyl-tin hydride; tetrabutylammonium (cyano)trihydroborate; potassium carbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; toluene;
DOI:10.1021/jo971703a