N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide
CAS No.:201420-70-4
Molecular Formula:C₅₈H₅₁N₅O₆SeSi
Molecular Weight:1021.12
Hs Code.:

N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Synonyms:N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

There total 11 articles about N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 18419-53-9
vinyldiphenylchlorosilane

: 201420-69-1
N-(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-5-phenylselanyl-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

: 201420-70-4
N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: With dmap; triethylamine; In toluene; for 15h; Ambient temperature;
DOI:10.1021/jo971703a

Reference yield:

: 5707-04-0
Phenylselenyl chloride

: 201420-70-4
N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) (COCl)2, DMSO, Et₃N, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 1.5 h, 2.) CH₂Cl₂, -78 deg C, 30 min, 0 deg C, 1.5 h

2: 72 percent / Bu₄NBH₃CN / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 0 deg C, 1.5 h

3: 1.) K₂CO₃, 2.) NH₃ / 1.) MeOH, room temp., 10 min, 2.) MeOH, 10 min

4: 100 percent / pyridine / 48 h / Ambient temperature

5: 93 percent / Et₃N, DMAP / toluene / 15 h / Ambient temperature

With dmap; oxalyl dichloride; ammonia; tetrabutylammonium (cyano)trihydroborate; potassium carbonate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; pyridine; toluene;
DOI:10.1021/jo971703a

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 201420-70-4
N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(diphenyl-vinyl-silanyloxy)-5-phenylselanyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / 48 h / Ambient temperature

2: 93 percent / Et₃N, DMAP / toluene / 15 h / Ambient temperature

With dmap; triethylamine; In pyridine; toluene;
DOI:10.1021/jo971703a