8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

Base Information

Chemical Name:8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione
CAS No.:1607837-44-4
Molecular Formula:C₂₃H₂₃ClN₆O₂
Molecular Weight:450.928
Hs Code.:

Synonyms:8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

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Chemical Property of 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

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Technology Process of 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

There total 8 articles about 8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1607838-05-0
8-(2-(bis(4-methoxybenzyl)amino)-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

: 1607837-44-4
8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: 637-87-6
1-Chloro-4-iodobenzene

: 1607837-44-4
8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; tetrahydrofuran / 80 °C

2: potassium acetate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 85 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / acetonitrile; water / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid / 1 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; trifluoroacetic acid; XPhos; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 1607838-03-8
5-bromo-3,4-dichloro-N,N-bis(4-methoxybenzyl)pyridin-2-amine

: 1607837-44-4
8-(2-amino-3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2,8-diazaspiro[4.5]decane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one; potassium fluoride; triethylamine / 2 h / 220 °C / Microwave irradiation; Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / acetonitrile; water / 1 h / 120 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid / 1 h / 20 °C

With 1-methyl-pyrrolidin-2-one; potassium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; trifluoroacetic acid; In water; acetonitrile;