3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Base Information

Chemical Name:3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide
CAS No.:1373687-44-5
Molecular Formula:C₁₅H₁₄FN₃
Molecular Weight:255.295
Hs Code.:

Synonyms:3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Suppliers and Price of 3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

There total 7 articles about 3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1373687-42-3
3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinonitrile

: 1373687-44-5
3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Guidance literature:: With trimethylaluminum; ammonium chloride; In toluene; at 0 - 100 ℃; for 26h; Inert atmosphere;
DOI:10.1016/j.ejmech.2021.113270

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1373687-44-5
3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 0 °C

1.2: 1.5 h / 0 °C

2.1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 18 h / 65 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / tetrahydrofuran; water / 14 h / 70 °C

4.1: trimethylaluminum; ammonium chloride / toluene / 26 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; trimethylaluminum; potassium acetate; potassium carbonate; ammonium chloride; In tetrahydrofuran; 1,4-dioxane; water; toluene;

Reference yield:

: 1373687-40-1
2-(2-(2-fluorophenyl)prop-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1373687-44-5
3-(2-(2-fluorophenyl)prop-1-en-1-yl)isonicotinimidamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / tetrahydrofuran; water / 14 h / 70 °C

2: trimethylaluminum; ammonium chloride / toluene / 26 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trimethylaluminum; potassium carbonate; ammonium chloride; In tetrahydrofuran; water; toluene;