N-(4-methoxyphenyl)-2-methyl-propanamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-2-methyl-propanamide
• CAS No.: 6642-37-1
• Molecular Formula: C11H15 N O2
• Molecular Weight: 193.246
• Hs Code.: 2924299090
• Mol file: 6642-37-1.mol

Synonyms:p-Isobutyranisidide(7CI,8CI); NSC 15678

Chemical Property of N-(4-methoxyphenyl)-2-methyl-propanamide

Chemical Property:

• Vapor Pressure: 2.57E-05mmHg at 25°C
• Melting Point: 108-110 °C
• Boiling Point: 358.3°C at 760 mmHg
• PKA: 14.28±0.70(Predicted)
• Flash Point: 170.5°C
• PSA: 38.33000
• Density: 1.074g/cm³
• LogP: 2.36270

Purity/Quality:

N-(4-METHOXY-PHENYL)-ISOBUTYRAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-methoxyphenyl)-2-methyl-propanamide

There total 12 articles about N-(4-methoxyphenyl)-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ISOPROPYLAMIDE (563-83-7) + 4-chloromethoxybenzene (623-12-1) → N-(4-methoxyphenyl)isobutyramide (6642-37-1)

Guidance literature:

With tri(sec-butyl)borane; (DiMeIHeptCl)Pd(cinammyl)Cl; caesium carbonate; In toluene; at 90 ℃; for 24h; Inert atmosphere; Sealed tube; Schlenk technique;

DOI:10.1021/jacs.7b09488

Reference yield: 88.0%

4-methoxyisobutyrophenone (2040-20-2) → N-(4-methoxyphenyl)isobutyramide (6642-37-1)

Guidance literature:

With hydroxylamine hydrochloride; trifluoroacetic acid; at 70 ℃; for 12h; regioselective reaction; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1021/acs.orglett.7b02105

Reference yield: 68.0%

phenyl isobutyrate (20279-29-2) + 4-methoxy-aniline (104-94-9) → N-(4-methoxyphenyl)isobutyramide (6642-37-1)

Guidance literature:

With C₄₀H₅₄ClN₂Pd; caesium carbonate; In tetrahydrofuran; water; at 40 ℃; for 8h; Glovebox; Inert atmosphere;

DOI:10.1021/acs.joc.7b02588

upstream raw materials:

N-cinnamylidene-p-anisidine

Thioisobutyric acid S-pyridin-2-yl ester

N-4-methoxyphenyl-α-methylcinnamylideneamine

N-(4-Methoxyphenyl)cyclohexylacetaldimine

Downstream raw materials:

Dimethylketen-p-anisylimin