4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Base Information

• Chemical Name: 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid
• CAS No.: 910035-29-9
• Molecular Formula: C₂₀H₂₁N₂O₁₀P
• Molecular Weight: 480.368
• Mol file: 910035-29-9.mol

Synonyms:4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Chemical Property of 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

There total 5 articles about 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-acetylphenyl)phosphono]butanoate (910035-15-3) → 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid (910035-29-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8) → 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid (910035-29-9)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 76 h / 20 °C

2: oxalyl chloride; dimethylformamide / CH₂Cl₂ / 2 h / Heating

3: 85 percent / NaH / tetrahydrofuran / 0 - 20 °C

4: NaOH / H₂O; tetrahydrofuran / 15 h / 20 °C

With sodium hydroxide; thionyl chloride; oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

C13H15Cl2N2O7P (910035-11-9) → 4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid (910035-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NaH / tetrahydrofuran / 0 - 20 °C

2: NaOH / H₂O; tetrahydrofuran / 15 h / 20 °C

With sodium hydroxide; sodium hydride; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2006.05.008

upstream raw materials:

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-[bis(4-acetylphenyl)phosphono]butanoate

C₁₃H₁₅Cl₂N₂O₇P

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate