methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

Base Information

• Chemical Name: methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate
• CAS No.: 910035-09-5
• Molecular Formula: C₁₃H₁₇N₂O₉P
• Molecular Weight: 376.26
• Mol file: 910035-09-5.mol

Synonyms:

Chemical Property of methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate

There total 2 articles about methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzyl chloroformate (4457-32-3) → methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate (910035-09-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / NaHCO₃; NaOH / H₂O; diethyl ether / 26 h / 20 °C

2: thionyl chloride / 76 h / 20 °C

With sodium hydroxide; thionyl chloride; sodium hydrogencarbonate; In diethyl ether; water;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid (288607-57-8) + methanol (67-56-1) → methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate (910035-09-5)

Guidance literature:

With thionyl chloride; at 20 ℃; for 76h;

DOI:10.1016/j.bmc.2006.05.008

Reference yield:

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoate (910035-09-5) → C13H15Cl2N2O7P (910035-11-9)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Heating;

DOI:10.1016/j.bmc.2006.05.008

upstream raw materials:

2-(N-4-nitrobenzyloxycarbonylamino)-4-phosphonobutanoic acid

methanol

4-nitrobenzyl chloroformate

Downstream raw materials:

C₁₃H₁₅Cl₂N₂O₇P

4-(hydroxy-phenoxy-phosphoryl)-2-(4-nitro-benzyloxycarbonylamino)-butyric acid

methyl 2-(N-4-nitrobenzyloxycarbonylamino)-4-(diphenylphosphono)butanoate

4-[(4-acetyl-phenoxy)-hydroxy-phosphoryl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid