(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Base Information

Chemical Name:(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate
CAS No.:1361050-74-9
Molecular Formula:C₁₅H₁₈F₃NO₄
Molecular Weight:333.307
Hs Code.:

Synonyms:(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Chemical Property:

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Technology Process of (R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

There total 3 articles about (R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1361050-70-5
(R)-4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

: 67-63-0,8013-70-5
isopropyl alcohol

: 1361050-74-9
(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; for 2h; Reflux; Inert atmosphere;

Reference yield:

: 1361050-65-8
(E)-1-benzyl-4-methyl-2-(2,4,5-trifluorobenzylidene)succinate

: 1361050-74-9
(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2250.23 Torr

2: (+)-cinchonine / acetone / Resolution of racemate; Reflux

3: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

With (+)-cinchonine; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; acetone; 3: Curtius Rearrangement;

Reference yield:

: 1361050-69-2
4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

: 1361050-74-9
(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: (+)-cinchonine / acetone / Resolution of racemate; Reflux

2: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

With (+)-cinchonine; diphenyl phosphoryl azide; triethylamine; In acetone; 2: Curtius Rearrangement;