(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

Base Information

Chemical Name:(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid
CAS No.:1361050-76-1
Molecular Formula:C₁₄H₁₆F₃NO₄
Molecular Weight:319.281
Hs Code.:

Synonyms:(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

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Chemical Property of (R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

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Technology Process of (R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

There total 4 articles about (R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1361050-74-9
(R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate

: 1361050-76-1
(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: (R)-methyl-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoate; With water; sodium hydroxide; In methanol; at 20 ℃; for 4h;

With hydrogenchloride; In methanol; water; at 20 ℃; pH=2;

Reference yield:

: 1361050-65-8
(E)-1-benzyl-4-methyl-2-(2,4,5-trifluorobenzylidene)succinate

: 1361050-76-1
(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 20 °C / 2250.23 Torr

2.1: (+)-cinchonine / acetone / Resolution of racemate; Reflux

3.1: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

4.1: sodium hydroxide; water / methanol / 4 h / 20 °C

4.2: 20 °C / pH 2

With (+)-cinchonine; diphenyl phosphoryl azide; water; hydrogen; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In methanol; acetone; 3.1: Curtius Rearrangement;

Reference yield:

: 1361050-70-5
(R)-4-methoxy-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

: 1361050-76-1
(R)-3-(isopropoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; diphenyl phosphoryl azide / 2 h / Reflux; Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: 20 °C / pH 2

With diphenyl phosphoryl azide; water; triethylamine; sodium hydroxide; In methanol; 1.1: Curtius Rearrangement;