(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid

Base Information

• Chemical Name: (3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid
• CAS No.: 382150-21-2
• Molecular Formula: C₁₆H₁₈O₄S
• Molecular Weight: 306.383
• Mol file: 382150-21-2.mol

Synonyms:(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid

Chemical Property of (3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid

There total 1 articles about (3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester (65434-72-2) + (E)-3-phenylthio-2-methylpropen-1-al (382150-12-1) → (3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid (382150-21-2)

Guidance literature:

With hydroquinone; In toluene; at 20 ℃; for 120h;

DOI:10.1021/jo010552f

Reference yield: 86.0%

(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid (382150-21-2) → 4-thiophenyl-5-methyl-3-hydroxybenzoic acid ethyl ester

Guidance literature:

(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid; With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 1h; Further stages.;

DOI:10.1021/jo010552f

Reference yield: 85.0%

(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid (382150-21-2) + methyl iodide (74-88-4) → (3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid (382150-24-5)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1021/jo010552f

upstream raw materials:

2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester

(E)-3-phenylthio-2-methylpropen-1-al

Downstream raw materials:

(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid