(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

Base Information

Chemical Name:(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid
CAS No.:382150-24-5
Molecular Formula:C₁₇H₂₀O₄S
Molecular Weight:320.409
Hs Code.:

Synonyms:(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

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Chemical Property of (3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

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Technology Process of (3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

There total 3 articles about (3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 382150-21-2
(3E,5E)-3-(ethoxycarbonyl)-5-methyl-6-thiophenyl-3,5-hexadienoic acid

: 74-88-4
methyl iodide

: 382150-24-5
(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;
DOI:10.1021/jo010552f

Reference yield:

: 65434-72-2
2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester

: 382150-24-5
(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / hydroquinone / toluene / 120 h / 20 °C

2: 85 percent / LDA; DMPU / tetrahydrofuran / -78 - 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydroquinone; lithium diisopropyl amide; In tetrahydrofuran; toluene; 1: Wittig reaction;
DOI:10.1021/jo010552f

Reference yield:

: 382150-12-1
(E)-3-phenylthio-2-methylpropen-1-al

: 382150-24-5
(3E,5E)-2,5-dimethyl-3-(ethoxycarbonyl)-6-thiophenyl-3,5-hexadienoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / hydroquinone / toluene / 120 h / 20 °C

2: 85 percent / LDA; DMPU / tetrahydrofuran / -78 - 0 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; hydroquinone; lithium diisopropyl amide; In tetrahydrofuran; toluene; 1: Wittig reaction;
DOI:10.1021/jo010552f