<1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester

Base Information

• Chemical Name: <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester
• CAS No.: 129151-97-9
• Molecular Formula: C₂₁H₂₃NO₇
• Molecular Weight: 401.416
• Mol file: 129151-97-9.mol

Synonyms:<1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester

Chemical Property of <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester

There total 4 articles about <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester (107967-05-5) + methyl iodide (74-88-4) → <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester (129151-97-9)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) mineral oil, DMF, ice-bath, 5 min, 2.) r.t., 2,25 h;

DOI:10.1021/jo00308a013

Reference yield:

dimethyl 2-(4-methoxybenzylidene)malonate (7443-25-6) → <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester (129151-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00082a020

Reference yield:

1-methyl-2-nitrobenzene (88-72-2) → <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester (129151-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 20 min, 2.) DMF, 0 deg C, 4 h

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00082a020

upstream raw materials:

[1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester

methyl iodide

1-methyl-2-nitrobenzene

dimethyl 2-(4-methoxybenzylidene)malonate

Downstream raw materials:

trans-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

cis-3-methyl-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride

(3R,4S)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

(3S,4R)-4-(4-Methoxy-phenyl)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-3-carboxylic acid methyl ester