1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone

Base Information

• Chemical Name: 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone
• CAS No.: 118171-09-8
• Molecular Formula: C₂₂H₃₀O₃Si
• Molecular Weight: 370.564
• Mol file: 118171-09-8.mol

Synonyms:1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone

Chemical Property of 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone

There total 5 articles about 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-2-trimethylsilanyloxy-pentan-3-one (118171-08-7) → 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone (118171-09-8)

Guidance literature:

With acetic acid; In tetrahydrofuran; water; at 25 ℃; for 48h;

DOI:10.1021/jo00263a007

Reference yield:

1-(tert-butyldiphenylsilyloxy)-2-propanone (118171-02-1) → 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone (118171-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium cyanide/ 18-crown-6 / 48 h / Ambient temperature

2: diethyl ether; benzene / 48 h / Ambient temperature

With potassium cyanide; 18-crown-6 ether; In diethyl ether; benzene;

DOI:10.1021/jo00263a007

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 1-<(tert-butyldiphenylsilyl)oxy>-2-hydroxy-2-methyl-3-pentanone (118171-09-8)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine, 4-(dimethylamino)pyridine / CH₂Cl₂ / 48 h

2: potassium cyanide/ 18-crown-6 / 48 h / Ambient temperature

3: diethyl ether; benzene / 48 h / Ambient temperature

With dmap; potassium cyanide; 18-crown-6 ether; triethylamine; In diethyl ether; dichloromethane; benzene;

DOI:10.1021/jo00263a007

upstream raw materials:

ethylmagnesium bromide

3-<(tert-butyldiphenylsilyl)oxy>-2-methyl-2-<(trimethylsilyl)oxy>propanenitrile

1-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-2-trimethylsilanyloxy-pentan-3-one

1-(tert-butyldiphenylsilyloxy)-2-propanone

Downstream raw materials:

2,4-dimethyl-4-(hydroxymethyl)tetronic acid

5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3,5-dimethyl-5H-furan-2-one