Technology Process of tert-butyl (R)-2-benzylazetidine-2-carboxylate
There total 7 articles about tert-butyl (R)-2-benzylazetidine-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C22H27NO2;
With
hydrogenchloride;
In
methanol;
at 0 - 20 ℃;
for 0.333333h;
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
at 20 ℃;
for 24h;
DOI:10.1039/c8ob01395k
- Guidance literature:
-
C20H22ClNO2; ethylene dibromide;
With
((11bS)-(+)-4,4-dibutyl-4,5-dihydro-2,6-bis(3,4,5-triflourophenyl)-3H-dinaphth[2,1-c:1’,2’-e]azepinium bromide); cesiumhydroxide monohydrate;
In
toluene;
at 0 ℃;
for 24h;
With
hydrogenchloride; water;
In
ethyl acetate;
at 20 ℃;
for 1h;
optical yield given as %ee;
enantioselective reaction;
Further stages;
DOI:10.1016/j.tet.2010.01.105
- Guidance literature:
-
C20H22ClNO2; 1-chloro-2-iodoethane;
With
((11bS)-(+)-4,4-dibutyl-4,5-dihydro-2,6-bis(3,4,5-triflourophenyl)-3H-dinaphth[2,1-c:1’,2’-e]azepinium bromide); cesiumhydroxide monohydrate;
In
toluene;
at 0 ℃;
for 24h;
With
hydrogenchloride; water;
In
ethyl acetate;
at 20 ℃;
for 1h;
optical yield given as %ee;
enantioselective reaction;
Further stages;
DOI:10.1016/j.tet.2010.01.105
