2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

Base Information

Chemical Name:2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester
CAS No.:86662-05-7
Molecular Formula:C₂₅H₂₆BrN₃O₅S₂
Molecular Weight:592.535
Hs Code.:

Synonyms:2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

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Chemical Property of 2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

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Technology Process of 2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

There total 4 articles about 2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 86662-11-5
N-(2-bromoethyl)-2'-isothiocyanato-4'-methoxytosylanilide

: 134-20-3
2-carbomethoxyaniline

: 86662-05-7
2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

Guidance literature:: In diethyl ether; for 3h; Heating;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 3360-81-4
N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide

: 86662-05-7
2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / K₂CO₃ / dimethylformamide / on steam bath

2: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

3: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

4: 75 percent / diethyl ether / 3 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91886-1

Reference yield:

: 16058-88-1
N-(2-Bromoethyl)-N-tosyl-4-methoxy-2-nitraniline

: 86662-05-7
2-(3-{2-[(2-Bromo-ethyl)-(toluene-4-sulfonyl)-amino]-5-methoxy-phenyl}-thioureido)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂ / 5percent Pd-C / ethanol; dioxane / Ambient temperature

2: 89 percent / H₂O / 1) 0 deg C, 2 h, 2) 4 deg C, several hours

3: 75 percent / diethyl ether / 3 h / Heating

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; diethyl ether; ethanol; water;
DOI:10.1016/S0040-4020(01)91886-1