2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde

Base Information

• Chemical Name: 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde
• CAS No.: 154989-52-3
• Molecular Formula: C₁₈H₁₇NO₃
• Molecular Weight: 295.338
• Mol file: 154989-52-3.mol

Synonyms:2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde

Chemical Property of 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde

There total 1 articles about 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-methoxy-benzaldehyde (123-11-5) + 3-formyl-1-methylindole-2-carbonitrile (154379-85-8) → 2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde (154989-52-3)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

DOI:10.1039/c39930001277

Reference yield: 94.0%

2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde (154989-52-3) → 2-(4-methoxy-benzoyl)-1-methyl-1H-indole-3-carbaldehyde (205520-04-3)

Guidance literature:

With dipyridinium dichromate; 4 A molecular sieve; In dichloromethane; at 25 ℃;

DOI:10.1021/jo9720795

Reference yield: 63.0%

2-[Hydroxy-(4-methoxy-phenyl)-methyl]-1-methyl-1H-indole-3-carbaldehyde (154989-52-3) → 4-methyl-3-(4-methoxyphenyl)thieno[3,4-b]indole

Guidance literature:

With Lawessons reagent; In 1,4-dioxane; for 4h; Heating;

DOI:10.1021/jo9720795

upstream raw materials:

4-methoxy-benzaldehyde

3-formyl-1-methylindole-2-carbonitrile

Downstream raw materials:

2-(4-methoxy-benzoyl)-1-methyl-1H-indole-3-carbaldehyde

(E,E)-bis{2-[1-hydroxy-(4-methoxyphenyl)methyl]-1-methylindole-3-carboxaldehyde} hydrazone