(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

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Chemical Name:(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid
CAS No.:1033881-29-6
Molecular Formula:C₂₆H₃₉N₅O₅
Molecular Weight:501.626
Hs Code.:

Synonyms:(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

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Chemical Property of (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

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Technology Process of (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

There total 1 articles about (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1033881-27-4
(1R,2S)-methyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylate

: 1033881-29-6
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

Guidance literature:: (1R,2S)-methyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylate; With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol;

Reference yield: 51.0%

: 402960-19-4
3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide

: 1033881-29-6
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

: 1033881-31-0
N-((1S)-1-cyclohexyl-2-((2S)-1-((1S,2R)-2-(1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)cyclohexylamino)-3,3-dimethyl-1-oxobutan-2-ylamino)-2-oxoethyl)pyrazine-2-carboxamide

Guidance literature:: (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 0.5h;

3-(S)-3-amino-N-cyclopropyl-2-hydroxyhexanamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

Reference yield: 38.0%

: 3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide

: 1033881-29-6
(1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid

: 1033881-35-4
N-((1S)-1-cyclohexyl-2-((2S)-1-((1S,2R)-2-((3S)-1-(2-((S)-2-(dimethylamino)-2-oxo-1-phenylethylamino)-2-oxoethylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)cyclohexylamino)-3,3-dimethyl-1-oxobutan-2-ylamino)-2-oxoethyl)pyrazine-2-carboxamide

Guidance literature:: (1R,2S)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanamido)cyclohexanecarboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 25 ℃; for 0.333333h;

3-amino-2-hydroxy-hexanoic acid {[(dimethylcarbamoyl-phenyl-methyl)-carbamoyl]-methyl}-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;