Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

Base Information

Chemical Name:Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester
CAS No.:915314-95-3
Molecular Formula:C₂₅H₃₄ClO₆P
Molecular Weight:496.968
Hs Code.:

Synonyms:Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

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Chemical Property of Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

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Technology Process of Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

There total 4 articles about Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155589-48-3
4‐chlorobutylzinc bromide

: 915314-86-2
(4S,7S)-4,7-Bis-benzyloxymethyl-2-methoxy-4,7-dihydro-[1,3,2]dioxaphosphepine 2-oxide

: 915314-95-3
Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

Guidance literature:: 4‐chlorobutylzinc bromide; With CuCN*2LiCl; In tetrahydrofuran; at -30 - -25 ℃; for 1h;

(4S,7S)-4,7-Bis-benzyloxymethyl-2-methoxy-4,7-dihydro-[1,3,2]dioxaphosphepine 2-oxide; In tetrahydrofuran; for 2h;
DOI:10.1021/ol061756r

Reference yield:

: 915315-05-8
bis((S)-1-(benzyloxy)but-3-en-2-yl) methyl phosphate

: 915314-95-3
Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 68 percent / (IMesH₂)(PCy₃)Cl₂Ru=CHPh / toluene / 0.5 h / Heating

2.1: CuCN*2LiCl / tetrahydrofuran / 1 h / -30 - -25 °C

2.2: tetrahydrofuran / 2 h

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; toluene;
DOI:10.1021/ol061756r

Reference yield:

: 109613-59-4
(S)-1-(benzyloxy)but-3-en-2-ol

: 915314-95-3
Phosphoric acid (1S,2R)-1-benzyloxymethyl-2-((E)-3-benzyloxy-propenyl)-6-chloro-hexyl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / BuLi / tetrahydrofuran / -30 - 20 °C

2.1: 68 percent / (IMesH₂)(PCy₃)Cl₂Ru=CHPh / toluene / 0.5 h / Heating

3.1: CuCN*2LiCl / tetrahydrofuran / 1 h / -30 - -25 °C

3.2: tetrahydrofuran / 2 h

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; n-butyllithium; In tetrahydrofuran; toluene;
DOI:10.1021/ol061756r