4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Base Information

Chemical Name:4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one
CAS No.:1266245-05-9
Molecular Formula:C₁₉H₂₀F₄N₄O₃
Molecular Weight:428.386
Hs Code.:

Synonyms:4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

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Chemical Property of 4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

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Technology Process of 4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

There total 6 articles about 4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1266244-70-5
(2-methyl-3-oxo-2,3-dihydro-pyridazin-4-ylamino)-acetic acid

: 1266245-86-6
4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidine

: 1266245-05-9
4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1266245-05-9
4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 20 - 70 °C

2.1: triethylamine; hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 48 h / 20 °C / 4500.45 Torr

3.1: hydrazine hydrate / 3 h / 80 °C

4.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / toluene; ethanol / 20 h / 20 °C / 4500.45 Torr

5.1: sodium hydroxide; water / methanol / 3.5 h / 0 - 20 °C

5.2: pH 3

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; caesium carbonate; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;

Reference yield:

: 13563-36-5
2-methyl-4-amino-3(2H)-pyridazinone

: 1266245-05-9
4-{2-[4-(5-fluoro-2-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / toluene; ethanol / 20 h / 20 °C / 4500.45 Torr

2.1: sodium hydroxide; water / methanol / 3.5 h / 0 - 20 °C

2.2: pH 3

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

With hydrogenchloride; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; toluene;