N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426530-75-7
Molecular Formula:C₃₂H₃₀FN₇O₂
Molecular Weight:563.634
Hs Code.:

Synonyms:N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

There total 7 articles about N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1426530-69-9
7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1692-25-7
3-pyridylboronic acid

: 1426530-75-7
N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; In N,N-dimethyl-formamide; at 85 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b00703

Reference yield:

: 1426530-69-9
7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1692-25-7
3-pyridylboronic acid

: 131534-65-1
pyridine-3-boronic acid 1,3-propanediol cyclic ester

: 1426530-75-7
N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide; 3-pyridylboronic acid; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; triethylamine; In N,N-dimethyl-formamide; at 85 ℃;

pyridine-3-boronic acid 1,3-propanediol cyclic ester; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; at 85 - 100 ℃;

Reference yield:

: 1426530-70-2
3-[(7-bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluoro-benzoic acid methyl ester

: 1426530-75-7
N-(2-fluoro-5-((2-(4-methylpiperazin-1-yl)benzyl)carbamoyl)phenyl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 80 °C

2: triethylamine; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; caesium carbonate; triethylamine; In N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.6b00703