7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426530-69-9
Molecular Formula:C₂₇H₂₆BrFN₆O₂
Molecular Weight:565.445
Hs Code.:

Synonyms:7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 5 articles about 7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 655256-68-1
(2-(4-methylpiperazin-1-yl)phenyl)methanamine

: 1426530-70-2
3-[(7-bromo-imidazo[1,2-a]pyridine-3-carbonyl)-amino]-4-fluoro-benzoic acid methyl ester

: 1426530-69-9
7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In toluene; at 80 ℃;
DOI:10.1021/acs.jmedchem.6b00703

Reference yield:

: 1019021-93-2
7-bromoimidazol[1,2-a]pyridine-3-carboxylic acid

: 1426530-69-9
7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1.5 h / Reflux

2: pyridine / toluene / 20 °C

3: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 80 °C

With pyridine; thionyl chloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In toluene;
DOI:10.1021/acs.jmedchem.6b00703

Reference yield:

: 1134327-98-2
7-bromoimidazo[1,2-a]pyridin-3-carboxylate ethyl ester

: 1426530-69-9
7-bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / methanol; water / 0.67 h / 60 °C

2.1: thionyl chloride / N,N-dimethyl acetamide / 0.5 h / 10 °C

2.2: 0.08 h / 30 °C

3.1: 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / toluene / 80 - 110 °C

With thionyl chloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; water; sodium hydroxide; In methanol; N,N-dimethyl acetamide; water; toluene;