Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
CAS No.:688790-01-4
Molecular Formula:C₂₄H₂₇N₄O₈PS₂
Molecular Weight:594.606
Hs Code.:

Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Synonyms:Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 3 articles about Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: ammonium bis-S-(2-cyanoethyl) phosphorodithioate

: 38558-16-6
5'-O-(phenoxyacetyl)thymidine

: 688790-01-4
Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With pyridine; 2,4,6-triisopropylphenylsulfonyl chloride; 3-nitro-1,2,4-triazole; at 20 ℃; for 1h;
DOI:10.1016/j.tetlet.2004.01.135

Reference yield:

: 701-99-5
Phenoxyacetyl chloride

: 688790-01-4
Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 2,6-lutidine / acetonitrile

2: 86 percent / 2,4,6-triisopropylbenzenesulfonyl chloride; 3-nitro-1,2,4-1H-triazole; pyridine / 1 h / 20 °C

With pyridine; 2,6-dimethylpyridine; 2,4,6-triisopropylphenylsulfonyl chloride; 3-nitro-1,2,4-triazole; In acetonitrile;
DOI:10.1016/j.tetlet.2004.01.135

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 688790-01-4
Phenoxy-acetic acid (2R,3S,5R)-3-[bis-(2-cyano-ethylsulfanyl)-phosphoryloxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 2,6-lutidine / acetonitrile

2: 86 percent / 2,4,6-triisopropylbenzenesulfonyl chloride; 3-nitro-1,2,4-1H-triazole; pyridine / 1 h / 20 °C

With pyridine; 2,6-dimethylpyridine; 2,4,6-triisopropylphenylsulfonyl chloride; 3-nitro-1,2,4-triazole; In acetonitrile;
DOI:10.1016/j.tetlet.2004.01.135