methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Base Information

Chemical Name:methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate
CAS No.:180406-53-5
Molecular Formula:C₁₈H₂₅NO₄S
Molecular Weight:351.467
Hs Code.:

Synonyms:methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Suppliers and Price of methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

There total 6 articles about methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 67-56-1
methanol

: 180406-52-4
(1R,2R,3S,4S,6S)-4-hydroxy-3-methyl-N-(p-tolylsulfonyl)-10-azatricyclo<4.3.1.0^2,4>decane

: 180406-53-5
methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Guidance literature:: With trifluorormethanesulfonic acid; bis-[(trifluoroacetoxy)iodo]benzene; for 0.0833333h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00073-3

Reference yield:

: 180406-57-9
N-p-tolylsulfonyl-9-azabicyclo<3.3.1>nonan-3-one

: 180406-53-5
methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / (S)-<2-(4-methylpiperazinyl)-1-phenylethyl>(2,2-dimethylpropyl)amine, n-BuLi, hexamethylphosphortriamide / tetrahydrofuran; hexane / 1.) -100 deg C to room temperature, 1 h, 2.) -100 deg C, 40 min

2: 1.) Et₂Zn, 2.) n-Bu₄NF / 1.) CH₂Cl₂, hexane, room temperature, 1 h, 2.) THF, room temperature, 20 min

3: 69 percent / phenyliodine bistrifluoroacetate, trifluoromethanesulfonic acid / 0.08 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; trifluorormethanesulfonic acid; (S)-2,2-dimethyl-N-(2-(4-methylpiperazin-1-yl)-1-phenylethyl)propan-1-amine; tetrabutyl ammonium fluoride; diethylzinc; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; hexane;
DOI:10.1016/S0040-4020(99)00073-3

Reference yield:

: 180406-45-5
(1R,5S)-N-(p-tolylsulfonyl)-3-(trimethylsilyloxy)-9-azabicyclo<3.3.1>non-2-ene

: 180406-53-5
methyl (2R,6S)-2-<(E)-1-propenyl>-N-(p-tolylsulfonyl)piperidine-6-ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₂Zn, 2.) n-Bu₄NF / 1.) CH₂Cl₂, hexane, room temperature, 1 h, 2.) THF, room temperature, 20 min

2: 69 percent / phenyliodine bistrifluoroacetate, trifluoromethanesulfonic acid / 0.08 h / Ambient temperature

With trifluorormethanesulfonic acid; tetrabutyl ammonium fluoride; diethylzinc; bis-[(trifluoroacetoxy)iodo]benzene;
DOI:10.1016/S0040-4020(99)00073-3