C₂₇H₃₇NO₅

Base Information

• Chemical Name: C₂₇H₃₇NO₅
• CAS No.: 1370354-77-0
• Molecular Formula: C₂₇H₃₇NO₅
• Molecular Weight: 455.594
• Mol file: 1370354-77-0.mol

Synonyms:C₂₇H₃₇NO₅

Chemical Property of C₂₇H₃₇NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₇NO₅

There total 3 articles about C₂₇H₃₇NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2R)-2-[(R)-3-(benzyloxy)pyrrolidin-1-yl]cyclohexanol (900513-88-4) + 2-(3,4-dimethoxyphenyl)oxirane (140687-75-8,102104-61-0) → C27H37NO5 (1370354-77-0) + C27H37NO5 (1370354-64-5)

Guidance literature:

(1R,2R)-2-[(R)-3-(benzyloxy)pyrrolidin-1-yl]cyclohexanol; With sodium hydride; In hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); mineral oil; at 45 ℃; for 0.5h; Inert atmosphere; Cooling with ice;

2-(3,4-dimethoxyphenyl)oxirane; In hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); mineral oil; at 20 - 70 ℃; for 70.5833h; Inert atmosphere;

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → C27H37NO5 (1370354-77-0) + C27H37NO5 (1370354-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water / 6 h / 85 °C

1.2: 16 h / 20 °C

1.3: 1 h / 20 °C

2.1: sodium hydride / hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); mineral oil / 0.5 h / 45 °C / Inert atmosphere; Cooling with ice

2.2: 70.58 h / 20 - 70 °C / Inert atmosphere

With sodium hydride; In hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); water; mineral oil;

Reference yield:

(3R)-N(H)-3-(benzyloxy)pyrrolidine (177948-70-8) → C27H37NO5 (1370354-77-0) + C27H37NO5 (1370354-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water / 6 h / 85 °C

1.2: 16 h / 20 °C

1.3: 1 h / 20 °C

2.1: sodium hydride / hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); mineral oil / 0.5 h / 45 °C / Inert atmosphere; Cooling with ice

2.2: 70.58 h / 20 - 70 °C / Inert atmosphere

With sodium hydride; In hexamethylphosphoramide (HMPA); methyl tert-butyl ether (MTBE); water; mineral oil;

upstream raw materials:

cyclohexane-1,2-epoxide

(3R)-N(H)-3-(benzyloxy)pyrrolidine

(1R,2R)-2-[(R)-3-(benzyloxy)pyrrolidin-1-yl]cyclohexanol

2-(3,4-dimethoxyphenyl)oxirane