900513-88-4

Basic information

• Product Name: 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol
• Synonyms: 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol;(1R,2R)-2-((R)-3-(benzyloxy)pyrrolidin-1-yl)cyclohexanol
• CAS NO: 900513-88-4
• Molecular Formula: C₁₇H₂₅NO₂
• Molecular Weight: 275.3859
• EINECS: -0
• Mol File: 900513-88-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 400.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• PKA: 14.95±0.40(Predicted)
• CAS DataBase Reference: 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol(900513-88-4)
• EPA Substance Registry System: 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol(900513-88-4)

Safety Data

• Hazardous Substances Data: 900513-88-4(Hazardous Substances Data)

Usage

General Description

2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol is a chemical compound that belongs to the class of cyclohexanols and contains a pyrrolidine ring. The compound has a cyclohexane ring and a pyrrolidine ring, with a benzyloxy group attached to the nitrogen atom of the pyrrolidine ring. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. The compound has potential applications in the field of medicinal chemistry and drug development due to its structural properties and functional groups, which can be modified to create new molecular entities with desired biological activities. Overall, 2-(3-Benzyloxy-pyrrolidin-1-yl)-cyclohexanol is a versatile chemical compound with potential applications in the pharmaceutical and chemical industries.

Upstream product

• 177948-70-8 (3R)-N(H)-3-(benzyloxy)pyrrolidine 
• 177947-67-0 (3R)-N-(tert-butyloxycarbonyl)-3-(benzyloxy)pyrrolidine 
• 100-39-0 benzyl bromide 
• 92645-06-2 (+/-)-trans-2-(N-benzyloxycarbonyl)aminocyclohexanol 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 143004-34-6 ethyl (R)-3-(benzyloxy)-4-chlorobutanoate 
• 1360870-97-8 (R)-4-(benzyloxy)-1-[(1R,2R)-2-(tert-butyldimethylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 286-20-4 cyclohexene oxide 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 795281-92-4 (3R)-3-benzyloxy-1-{(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl}pyrrolidine 
• 1370354-77-0 C₂₇H₃₇NO₅ 
• 1370354-64-5 C₂₇H₃₇NO₅ 

Relevant articles and documents

A fang chanfu law compound and its preparation method, pharmaceutical composition and use thereof

The invention relates to a new compound for conversion of auricular fibrillation, as shown in the general formula i in the specification (n in the formula is equal to 0 to 4), or pharmaceutically acceptable salt thereof. The invention also provides a novel compound used as a preventive medicine or therapeutic drug for atrial fibrillation, a preparation method and a pharmaceutical composition containing the compound.

PROCESS FOR PREPARATION OF AMINOCYCLOHEXYL ETHERS AND INTERMEDIATE PRODUCTS USED IN THE PROCESS

A process for preparation of a compound of formula (I) or or a pharmaceutically acceptable salt, ester, or prodrug thereof, is disclosed. The process involves hydrogenating, in the presence of a catalyst, a compound of formula (II). The different substituents are as described in the specification. Also disclosed are intermediates and processes for their preparation. Further, the process can provide an alternate route for the synthesis of Vernakalant from starting materials that can be readily available.

PRODUCTION METHOD OF OPTICALLY ACTIVE CYCLOHEXANE ETHER COMPOUNDS

The present invention relates to an industrial synthetic method of an optically active cyclohexane ether compound (IIIa) or a salt thereof, which is useful as a pharmaceutical agent, and an intermediate useful for the production method of the present invention. The production method of the present invention is as shown below: wherein each symbol is as defined in the specification. According to the production method of the present invention, efficient and stable supply of an optically active cyclohexane ether compound (IIIa) in a high yield at a lower cost can be afforded. Therefore, an optically active cyclohexane ether compound (IIIa) extremely useful as a pharmaceutical agent can be provided by an industrially highly advantageous method.