N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine

Base Information

• Chemical Name: N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine
• CAS No.: 1012064-12-8
• Molecular Formula: C₃₅H₄₆N₆O₁₂S₂
• Molecular Weight: 806.915

Synonyms:N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine

Chemical Property of N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine

There total 2 articles about N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.5%

N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)-1,3-propanediamine (240423-18-1) + N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane (425644-04-8) → N(12)-benzyloxycarbonyl-N(1)-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine (1012064-12-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 23h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.11.029

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N(12)-benzyloxycarbonyl-N(1)-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine (1012064-12-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: methanol / 24.58 h / 0 - 20 °C

1.2: 1 h

2.1: triethylamine / dichloromethane / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 23 h / 60 °C / Inert atmosphere

With potassium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2008.11.029

Reference yield:

N(12)-benzyloxycarbonyl-N(1)-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine (1012064-12-8) → C30H38N6O10S2 (1278496-12-0)

Guidance literature:

N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 1h;

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2008.11.029

upstream raw materials:

N-(tert-butoxycarbonyl)-N'-(2-nitrobenzenesulfonyl)-1,3-propanediamine

N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

N(12)-(Nα-benzyloxycarbonylasparaginyl)-4,8-di(tert-butoxycarbonyl)-N(1)-[Nα,Nε-di(tert-butoxycarbonyl)lysyl]-4,8-diaza-1,12-dodecanediamine

C₃₀H₃₈N₆O₁₀S₂

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