425644-04-8

Upstream product

• 109-64-8 1,3-dibromo-propane 
• 425644-02-6 N-(2-nitrobenzenesulfonyl)-N'-(benzyloxycarbonyl)-1,4-diaminobutane 
• 501-53-1 benzyl chloroformate 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 349553-74-8 N-(2-nitrobenzenesulfonyl)-1,4-diaminobutane hydrochloride 

Downstream Products

• 1012064-12-8 N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine 

Relevant academic research and scientific papers

An efficient synthesis of orthogonally protected spermidine

A major problem in the use of spermidine for the synthesis of biologically interesting compounds is the selective orthogonal protection of the three different amino groups. Our approach is based on the Fukuyama reaction, starting from putrescine and 3-amino-l-propanol and affording N8-benzyloxycarbonyl- N1-tert-butyloxycarbonyl- N4-(2-nitrobenzenesulfonyl)spermidine (5) in 5 steps in high yield.

Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.