N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane

Base Information

• Chemical Name: N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane
• CAS No.: 425644-04-8
• Molecular Formula: C₂₁H₂₆BrN₃O₆S
• Molecular Weight: 528.424
• Mol file: 425644-04-8.mol

Synonyms:N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane

Chemical Property of N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane

There total 4 articles about N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.9%

1,3-dibromo-propane (109-64-8) + N-(2-nitrobenzenesulfonyl)-N'-(benzyloxycarbonyl)-1,4-diaminobutane (425644-02-6) → N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane (425644-04-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.11.029

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane (425644-04-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 55 percent / N-methylmorpholine / tetrahydrofuran / 2 h

2: 78 percent / 1 N NaOH / dioxane / 0 - 20 °C

3: 65 percent / Cs₂CO₃ / dimethylformamide / 24 h / 60 °C

With 4-methyl-morpholine; sodium hydroxide; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1081/SCC-120002114

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane (425644-04-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / 1 N NaOH / dioxane / 0 - 20 °C

2: 65 percent / Cs₂CO₃ / dimethylformamide / 24 h / 60 °C

With sodium hydroxide; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1081/SCC-120002114

upstream raw materials:

1,3-dibromo-propane

N-(2-nitrobenzenesulfonyl)-N'-(benzyloxycarbonyl)-1,4-diaminobutane

benzyl chloroformate

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

N⁽¹²⁾-benzyloxycarbonyl-N⁽¹⁾-tert-butoxycarbonyl-4,8-di(2-nitrobenzenesulfonyl)-4,8-diaza-1,12-dodecanediamine