ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

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Chemical Name:ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate
CAS No.:1356602-57-7
Molecular Formula:C₃₃H₃₃NO₆S
Molecular Weight:571.694
Hs Code.:

Synonyms:ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

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Chemical Property of ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

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Technology Process of ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

There total 7 articles about ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1356602-55-5
ethyl 5-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-oxo-1,3-dioxolane-4-carboxylate

: 108-98-5
thiophenol

: 1356602-57-7
ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 - 60 ℃; for 12h; Inert atmosphere;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1356602-57-7
ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium acetate; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 - 80 °C

2.1: potassium carbonate / acetonitrile / 0.08 h / 20 °C

2.2: 5 h / 20 - 80 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

4.2: 12 h / 0 - 20 °C

5.1: osmium(VIII) oxide; potassium hexacyanoferrate(III); methanesulfonamide; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 12 h / 0 - 20 °C

6.1: pyridine / dichloromethane / 4 h / -78 - 20 °C

7.1: triethylamine / tetrahydrofuran / 12 h / 20 - 60 °C / Inert atmosphere

With pyridine; osmium(VIII) oxide; methanesulfonamide; di-isopropyl azodicarboxylate; sodium acetate; sodium hydride; potassium carbonate; acetic acid; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 142533-52-6
(Z)-2-bromo-1-phenylethanone O-methyl oxime

: 1356602-57-7
ethyl 3-hydroxy-3-{4-[(4-{[(2Z)-2-(methoxyimino)-2-phenylethyl]oxy}benzyl)oxy]phenyl}-2-(phenylsulfanyl)propanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / acetonitrile / 0.08 h / 20 °C

1.2: 5 h / 20 - 80 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

3.2: 12 h / 0 - 20 °C

4.1: osmium(VIII) oxide; potassium hexacyanoferrate(III); methanesulfonamide; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 12 h / 0 - 20 °C

5.1: pyridine / dichloromethane / 4 h / -78 - 20 °C

6.1: triethylamine / tetrahydrofuran / 12 h / 20 - 60 °C / Inert atmosphere

With pyridine; osmium(VIII) oxide; methanesulfonamide; di-isopropyl azodicarboxylate; sodium hydride; potassium carbonate; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; acetonitrile; tert-butyl alcohol;